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In 2016, a meta-analysis study conducted to investigate the relation between polymorphisms in TLR2, TLR4, TLR9, TNFRSF1A, IFN, IL-6, and IL-1 genes and therapy response among IBD cases [148]

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2) The sod1 mutant was markedly attenuated in virulence when raising the infection in mice, and it also showed significantly susceptibility to in vitro killing by human neutrophils